Multiple Sclerosis (MS) is a multifactorial disease that causes inflammation and demyelination in brain tissue eventually leading to damage in sensory and motor function. Research published in the Journal NeuroScience shows that MS affects about 350,000 people annually with its onset peak age of 20-40 years.
Multiple Sclerosis disproportionately affects more females than males at about a two to one ratio. Previous studies on MS have shown that it is a complex disease which has genetic, environmental and immunological factors that work together to manifest it.
However, research on how marrow stromal cells (MSCs) isolated in culture from the bone marrow in mice can be used in remyelinating demyelinated rat spinal cords shows that the search for MS treatment could be over.
In this study, the researchers injected isolated and cultured MSCs from GFP-expressing mice directly into lesions on rat spinal cords. To induce demyelination similar to that in MS patient brain, researchers created the lesions on rats using x-ray irradiation and ethidium bromide.
Overall, the researchers found strong evidence supporting the hypothesis that MSCs can be used in the remyelinating of white matter and potentially for the treatment of MS. For more on the research, you can click here